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Sometimes. It contains fixes for specific games and patches from wine-staging (the newest, testing branch) that are not included in Valve’s Proton releases, many of which have a positive impact on performance. The project’s overview is the best summary.
Or for in game cut scene/Media sometimes it is a must: Additional media foundation patches for better video playback support.
Depends on the game. For example I can’t get Persona 5 Strikers to run in Proton. No videos load or cutscenes. I’d I run it with Proton-GE (9.x), it works flawlessly.
