I feel like this also works for depression. I will go through half my library doing this, just to turn it off because there’s no desire for anything.

Trump should be “I don’t know”

I’d like to leave the United States first. Someplace diverse where I can walk or use public transit, and that has clean water and air. If there’s wilderness, hiking trails, or any other kind of nature relatively close that would be pretty swell.

My guess is he wants to live forever because he feels he has made no contribution to the world, or does not feel a sense of fulfillment and purpose from raising his family. Maybe he feels cracking the secret could be his contribution, or maybe he thinks he can find meaning in his life, given enough time.

Your levels are already too high for monotherapy. 250-300 is more than enough. Higher levels don’t produce better or faster results.

Austin, we won.

In his defense, it was a big rock.

I had two friends get angry at me (in one case yelling at me, the other storming out of our get together) when I brought up the new regime’s plan to end affirming care and legal recognition for trans folks.

I’m kind of utterly floored - this is widely available information, and in both cases, they were completely dismissive and outright hostile. And both are folks I’ve known for a pretty long time. One is even a trans woman (albeit a rich Caitlyn Jenner type who is totally divorced from what most trans folks experience).

It was a really awful way to end the first vacation I’ve had in years. Icing on the cake is I’m also having some kind of allergic reaction and my face looks awful.

Thank you for the thought-out response.

It doesn’t sound like site soreness, and if you’re using insulin needles, those are too small to get into the muscle anyway.

Your dose might be a little high, but I doubt it’s so high that it’s putting you at a risk for blood clots.

It honestly sounds like it could just be soreness from exercising more if you started doing that around the same time as injections, and your body isn’t used to it. It could also be an electrolyte imbalance, as some others mentioned, but if you’re young and relatively healthy that’s fairly unlikely.

I usually start with the most likely scenario and move from there. It’s pretty unlikely to be a DVT, injection site soreness, or electrolyte imbalance, so it’s likely just soreness. If you aren’t already, try adding some light stretching before or after you exercise. Applying heat should help, too, if it’s just muscle soreness. I would bring all this up with your doctor so they are able to rule out the more serious stuff, but I would not be overly concerned about it.

On a somewhat related note, when looking up medical information I would stick with Mayo Clinic or Cleveland Clinic for general medical stuff. For trans specific info, Fenway Health is the gold standard (imo), someone linked to them in a different response. You can also check WPATH standards of care 8, but that’s meant as more of a reference for medical professionals and it might be a bit dense.

Please let us know how it goes, and keep asking questions! It’s best to get from medical professionals, but sadly folks like us don’t always have that luxury.

Estrogen does not dilate blood vessels, and vasodilation won’t cause pain. It’s very unlikely that the hormone is causing the pain.

I have a few questions, if you don’t mind? You said you are doing the injections subcutaneous. Where are you injecting? What length of needle are you using? Subcutaneous injections are relatively painless and shouldn’t be causing any of the issues you are describing, but if you’re using a needle that is too big or injecting in a bad spot the pain could be related to injection site soreness.

Pain in the legs and below the knee could be a sign of deep vein thrombosis. It’s very unlikely, but estrogen can make you more susceptible to blood clots. You are at higher risk for this if you smoke cigarettes (especially if you’re over 35), if you have a more sedentary lifestyle, or if your serum estrogen level is too high. Subcutaneous injections tend to lead to higher serum estrogen levels, which can put you at a higher risk for blood clots.

You said you are DIY, is anyone checking your estrogen levels? What dose of estrogen are you taking, and how often?

It’s pretty unlikely the pain is from a DVT, but that is a very serious complication you need to rule out (a dislodged clot from a DVT that travels to your lungs can cause a pulmonary embolism, which can potentially be fatal).

I hope this doesn’t come across as condescending, but these are the questions I would ask if you were a patient.