Neomutt (with notmuch) is not easy when starting from scratch. Luckily there are some configurations online that get you up and running quickly. It still requires some efforts to get use to it and configured to your detailed and specific needs. I put sweat to build mine but it worth every single drop.
That being said that’s what makes its strength. It’s not an email client, it’s your email client. Once it’s configured, it’s good forever and using anything else feels like a pain.
I have gmail, exchange, and disroot accounts setup in neomutt. For gmail I had to generate an app specific password for neomutt because I use 2FA with gmail and neomutt doesn’t use Oauth2 as authentication method. Although, I was too lazy to try them, there are some options to use xoauth2. No surprise, exchange was the trickiest one to get working. I have to use Davmail for that. Behind an apparent complexity you just need your exchange email URL to get it running, and then you use the Davmail ports in neomutt.